منابع مشابه
Carcinogenicity of food mutagens.
Cancer cells are produced by the accumulation of genetic alterations in somatic cells. Those genetic alterations are produced by xenobiotics, which enter the human body from the environment, and by autobiotics, which are produced in the human body. Food contains many different types of xenobiotic mutagens/carcinogens and tumor promoters. Food can influence the formation of autobiotic mutagens/c...
متن کاملCarcinogenicity of mutagens: predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity.
A total of 224 chemicals that have been tested in long-term studies for carcinogenicity in rats and mice by the National Cancer Institute and the National Toxicology Program were tested for mutagenicity in Salmonella typhimurium. Correlations between mutagenicity and carcinogenicity were examined. The influences of chemical structure, rodent species and organ responses, and bacterial strain res...
متن کاملFood-derived Mutagens and Carcinogens1
Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents when given in the diet at 0.01-0.08%. Most of them induced cancer in the liver and in other organs. It is noteworthy that the most abundant heterocyclic amine in cooked food, 2-amino-l-methyl-6-phenylimidazo(4,5-A|pyridine, produced colon and mammary carcino...
متن کاملSynthesis and radiolabeling of heterocyclic food mutagens.
The imidazoquinoline and imidazoquinoxaline food mutagens found in cooked meat are being synthesized by unambiguous methods that allow for the preparation of sufficient quantities of material for biological studies. These methods avoid difficult separations of regioisomeric mixtures of products and are designed to allow incorporation of specific high level tritium labeling.
متن کاملMetabolic aspects of pyrolysis mutagens in food.
The first step in metabolic activation of mutagenic and carcinogenic heterocyclic amines has been elucidated to be N-hydroxylation by cytochrome P-448. N-Hydroxyamino compounds are further activated to form N-O-acyl derivatives that readily react with DNA. The adducts between the metabolites of Trp-P-2 and Glu-P-1 and DNA were shown to have a C8-guanylamino structure. In the case of Glu-P-1, mo...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1996
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.96104s3429